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KMID : 1188320100040040551
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Gut and Liver
2010 Volume.4 No. 4 p.551 ~ p.555
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Liver Cirrhosis Induced by Porphyria Cutanea Tarda: A Case Report and Review
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Lee Kwang-Gyun
Hyun Jong-Jin
Seo Yeon-Seok
Keum Bo-Ra
Yim Hyung-Joon
Jeen Yoon-Tae
Lee Hong-Sik
Chun Hoon-Jai
Kim Chang-Duck
Ryu Ho-Sang
Um Soon-Ho
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Abstract
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Porphyria cutanea tarda (PCT) is a metabolic disorder that results in a decrease in uroporphyrinogen decarboxylase activity. It is characterized by photosensitivity, bullae formation, and skin pigmentation. There are four types of PCT: acquired, familial, toxic, and hepatoerythropoietic. Uroporphyrin levels are elevated in the urine of PCT patients. PCT can be differentiated from other porphyrias by its clinical characteristics and the porphyrin levels in the serum, erythrocytes, urine, and feces. This metabolic disorder can lead to liver dysfunction as well as histological changes such as fatty infiltration or hepatic fibrosis. PCT rarely manifests as liver cirrhosis. We report herein a case of PCT-induced liver cirrhosis that progressed to hepatic failure.
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KEYWORD
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Porphyria cutanea tarda, Uroporphyrin, Metabolic disorder, Liver cirrhosis
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